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2004•Unpublished venueRequires access

The Role of Induced Sputum in Monitoring Airway Inflammation of Chronic Obstructive Pulmonary Disease

Yang La

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Abstract

Objective To investigate the role of induced sputum in monitoring airway inflammation of chronic obstructive pulmonary disease (COPD). Methods Induced sputum was taken from 26 patients with stable COPD. IL-8 level in the sputum was detected, and the lung function of the patients was determined. 15 healthy volunteers served as control group. Results The total cell count and the number of AM and PMN in sputum were significantly higher in the patients than those in the control group (P0.01). The IL-8 level in sputum was significantly higher in the patients than that in the control group (P0.01). There was negative correlation between IL-8 level and FEV 1 percentage in induced sputum (r=-0.539,P0.01), and between PMN number and FEV 1 percentage (r=-0.733,P0.01). There was no correlation between AM number and FEV 1 percentage (r=-0.223,P=0.161). Conclusion Induced sputum played a vital role in monitoring airway inflammation of COPD.

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What this paper is about

Objective To investigate the role of induced sputum in monitoring airway inflammation of chronic obstructive pulmonary disease (COPD). Methods Induced sputum was taken from 26 patients with stable COPD. IL-8 level in the sputum was detected, and the lung function of the patients was determined. 15 healthy volunteers served as control group. Results The total cell count and the number of AM and PMN in sputum were significantly higher in the patients than those in the control group (P0.01). The IL-8 level in sputum was significantly higher in the patients than that in the control group (P0.01). There was negative correlation between IL-8 level and FEV 1 percentage in induced sputum (r=-0.539,P0.01), and between PMN number and FEV 1 percentage (r=-0.733,P0.01). There was no correlation between AM number and FEV 1 percentage (r=-0.223,P=0.161). Conclusion Induced sputum played a vital role in monitoring airway inflammation of COPD.

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Available abstract

Objective To investigate the role of induced sputum in monitoring airway inflammation of chronic obstructive pulmonary disease (COPD). Methods Induced sputum was taken from 26 patients with stable COPD. IL-8 level in the sputum was detected, and the lung function of the patients was determined. 15 healthy volunteers served as control group. Results The total cell count and the number of AM and PMN in sputum were significantly higher in the patients than those in the control group (P0.01). The IL-8 level in sputum was significantly higher in the patients than that in the control group (P0.01). There was negative correlation between IL-8 level and FEV 1 percentage in induced sputum (r=-0.539,P0.01), and between PMN number and FEV 1 percentage (r=-0.733,P0.01). There was no correlation between AM number and FEV 1 percentage (r=-0.223,P=0.161). Conclusion Induced sputum played a vital role in monitoring airway inflammation of COPD.

Key concepts: Sputum, Medicine, COPD, Airway, Internal medicine, Inflammation, Pulmonary disease, Gastroenterology

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