A controlled study of effect on schizophrenia serum prolactin level aripiprazole

Objective To explore the in fluence of aripiprazole on schizophrenia serum prolactin level.Methods 60patients with schizophrenia were randomly divided into aripiprazole group(n=30)and risperidone group(n=30)for 8 weeks.The positive and negative synodrome scale(PANSS)was evaluated before and after 2、4、8 weeks.The PRL level was measured by radioimmunoassay Before,at the end of 4 week and 8 week.Results At the end 8th week,there were the most reduced significantly in the scores of PANSS between two groups than before evaluated(P0.01),but compared of two groups was no significant differences(P0.05); There was no significant difference in serum level of PRL before and after treatment in aripiprazole group(P0.05).However,the serum level of PRL increased highly after risperidone treatment(P0.05).Compared with patients in risperidone group(7/18,38.9%),patients in aripiprazole group seldom had menstruation dysfunction and lactation(P0.05).Conclusion Aripiprazole is better effective in the treatment of patients with schizophrenia,with less influence on serum PRL level.Aripiprazole is one of effective and safe drugs in the treatment of schizophrenia.