Serological analysis on 1778 pregnant women and neonates with syphilis

Objective:To provide a new basis for preventing and controlling project of maternal-infantile transmission of syphilis in Shenzhen city.Methods:The examined specimens from each hospital in Baoan district underwent toluidine red unheated serum test(TRUST) and treponema pallidum particle agglutination(TPPA) test simultaneously.Results:A total of 1 778 serum specimens of pregnant women and neonates were collected from January 1st,2008 to December 31st,2009.The positive rates of maternal serum specimens detected by TRUST and TPPA were 89.32%(920/1 030) and 79.80%(822/1 030),respectively.The positive rates of neonatal serum specimens detected by TRUST and TPPA were 50.00%(374/748) and 60.56%(453/748),respectively;TRUST titer of 3.07% of the neonates was more than 1∶ 8(including 1∶ 8);which was significantly lower than the percentage of pregnant women(20.10%).The true positive rate in 2009 was lower than that in 2008.Conclusion:Control work of syphilis among pregnant women and neonates can control maternal-infantile transmission of syphilis effectively,the screening of syphilis during the first trimester of pregnancy should be further enhanced.