2010•Medical Journal of National Defending Forces in Northwest ChinaRequires access
Effects of hyperoxic liquid on the expression of aquaporin-1 in lung tissue of rabbits with acute lung injury
Wu Ming
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Abstract
Objective:To investigate the effects of hyperoxic liquid on the expression of aquaporin-1(AQP-1) in lung tissue of rabbits with acute lung injury(ALI).Methods: Forty-five rabbits were randomly divided into three groups: control group(group A),ALI group(group B) and hyperoxic liquid group(group C).ALI model was established by an special impactor in group B and group C.The animals in group C were given Shuayangkang by intravenous infusion.Blood samples were taken for blood gas analysis at 0,0.5,1,2,4,6 h.The animals were killed after 6 h,the ratio of wet to dry lung weight was measured,and the changes of lung tissue were pathologically observed.The expression of AQP-1 was examined by immunohistochemical method.Results:The value of PaO2 and SpO2,and the expression of AQP-1 in lung tissue in group B decreased significantly compared with group A(P0.05),while the ratio of wet to dry lung weight increased significantly(P0.05).In group C,the values of PaO2 and SpO2,and the expression of AQP-1 increased significantly compared to those of group B(P0.05),the ratio of wet to dry lung weight increased significantly(P0.05).Conclusion:The hyperoxic liquid exerts protective effect on acute lung injury by regulating the expression of AQP-1 in lung tissue.