Clinical research of intestinal barrier dysfunction for severe acute pancreatitis patients with blood line infections

Objective To study the patients with acute pancreatitis blood line infection patients with intestinal barrier clinical correlation research and observation for severe acute pancreatitis blood line infection and the relationship between postoperative infection.Methods The data and cases accepted treatment for severe acute pancreatitis and diagnosed with blood line infected patients clinical treatment group,control group with the conventional treatment,the treatment group in the control group treatment on the basis of implementation of intestinal barrier early protection measures.Compared two groups gastrointestinal function score and APACHE Ⅱ score,C-reactive protein(CRP),serum tumor necrosis factor alpha(TNF alpha),plasma endotoxin level(LPS),urinary lactulose/mannitol value(L/M),and the two groups after treatment in patients with general condition comparison.Results The observation group after treatment,APACHE Ⅱ score,CRP,TNF alpha,LPS than before treatment down significantly,compared with controls differences also had statistical significance(P 0.01).Conclusion Early intestinal barrier function can effectively improve the protection of patients with gastrointestinal function,reduce the intestinal barrier permeability and inflammatory reaction.