ScholarLens Back to search
2007•Di-Si Junyi Daxue xuebaoRequires access

Change of Apaf-1 expression in hippo campal CA1 area after diffuse axonal injury in rats and its effect on neuron apoptosis

Li Jian

Open publisher page 0 citations

Abstract

AIM:To investigate the change of Apaf-1 expression and its effect on the neuron apoptosis in CA1 area of hippocampus after diffuse axonal injury in rats. METHODS: The models of severe closed brain injury were made by Marmarou method. The expression of Apaf-1 was detected by using immunohistochemistry. RESULTS: The expression of Apaf-1 began to increase 3 h after injury and reached the peak at 6 h, then remained at a high level at 12 h, and finally declined at 24 h, but was still higher than the normal. CONCLUSION: Apaf-1 might be associated with pathological changes of CA1 area of hippocampus after diffuse brain injury in rats.

About this research paper

What this paper is about

AIM:To investigate the change of Apaf-1 expression and its effect on the neuron apoptosis in CA1 area of hippocampus after diffuse axonal injury in rats. METHODS: The models of severe closed brain injury were made by Marmarou method. The expression of Apaf-1 was detected by using immunohistochemistry. RESULTS: The expression of Apaf-1 began to increase 3 h after injury and reached the peak at 6 h, then remained at a high level at 12 h, and finally declined at 24 h, but was still higher than the normal. CONCLUSION: Apaf-1 might be associated with pathological changes of CA1 area of hippocampus after diffuse brain injury in rats.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM:To investigate the change of Apaf-1 expression and its effect on the neuron apoptosis in CA1 area of hippocampus after diffuse axonal injury in rats. METHODS: The models of severe closed brain injury were made by Marmarou method. The expression of Apaf-1 was detected by using immunohistochemistry. RESULTS: The expression of Apaf-1 began to increase 3 h after injury and reached the peak at 6 h, then remained at a high level at 12 h, and finally declined at 24 h, but was still higher than the normal. CONCLUSION: Apaf-1 might be associated with pathological changes of CA1 area of hippocampus after diffuse brain injury in rats.

Key concepts: Hippocampus, Apoptosis, Immunohistochemistry, Neuron, Neuroprotection, Pathological, Neuroscience, Pathology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Change of Apaf-1 expression in hippo campal CA1 area after diffuse axonal injury in rats and its effect on neuron apoptosis — Research Paper | ScholarLens