Study of intensity modulated radiotherapy combined with concurrent chemotherapy after high-risk cervical cancer operation

Objective To study the treatment efficacy of intensity modulated radiotherapy(IMRT) instead of conventional radiotherapy,combined with Paclitaxel and Cisplatin in postoperative high-risk cervical cancer patients. Methods 60 cases of Ib-IIa cervical cancer patients were randomly selected and divided into 2 groups,both treatment with Paclitaxel and Cisplatin,and combined with intensity modulated radiotherapy to study group,but with conventional radiotherapy to control group. To analyze the efficacy and toxicity of the two groups were compared. Results(1) Comparing with the control group,2 year recurrence rate and distant metastasis rate were significantly lower in study group. The differences of above two indicators in the two groups was statistically significant(P0.05). However,the 2 year survival rate wasn't statistically significant(P0.05) in the two group.(2) Acute toxicity in gastrointestinal tract,urinary tract and hematopoietic system were significantly reduced,and chronic intestinal toxicity reaction also decreased(P0.05). Conclusion Comparing with the conventional radiotherapy,IMRT dose distributions and shape or boundary of target and critical organs are much closer in the 3D space,and the recurrence rate,distant metastasis rate and adverse reaction were reduced.