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2011•The Chinese Journal of Modern Applied PharmacyRequires access

Effect of pH on Apparent Oil/Water Partition Coefficient of Prodrugs of Indomethacin

Xu Zhi

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Abstract

OBJECTIVE To study the effect of pH on apparent oil/water partition coefficient of prodrugs of indomethacin.METHODS The apparent oil/water partition coefficient of prodrugs of indomethacin was measured by shaking flask method.The concentration of prodrugs of indomethacin was determined by UV.RESULTS When the temperature was 25 ℃,the prodrugs of indomethacin have the highest partition coefficients in n-octanol/pH 4 buffer solution system.CONCLUSION The apparent oil/water partition coefficients of prodrugs of indomethacin are correlated to pH of the medium and the polarity of group which is added.

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OBJECTIVE To study the effect of pH on apparent oil/water partition coefficient of prodrugs of indomethacin.METHODS The apparent oil/water partition coefficient of prodrugs of indomethacin was measured by shaking flask method.The concentration of prodrugs of indomethacin was determined by UV.RESULTS When the temperature was 25 ℃,the prodrugs of indomethacin have the highest partition coefficients in n-octanol/pH 4 buffer solution system.CONCLUSION The apparent oil/water partition coefficients of prodrugs of indomethacin are correlated to pH of the medium and the polarity of group which is added.

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Available abstract

OBJECTIVE To study the effect of pH on apparent oil/water partition coefficient of prodrugs of indomethacin.METHODS The apparent oil/water partition coefficient of prodrugs of indomethacin was measured by shaking flask method.The concentration of prodrugs of indomethacin was determined by UV.RESULTS When the temperature was 25 ℃,the prodrugs of indomethacin have the highest partition coefficients in n-octanol/pH 4 buffer solution system.CONCLUSION The apparent oil/water partition coefficients of prodrugs of indomethacin are correlated to pH of the medium and the polarity of group which is added.

Key concepts: Partition coefficient, Prodrug, Chemistry, Chromatography, Partition (number theory), Octanol, Biochemistry, Mathematics

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