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Dynamical changes of free radical and superoxide dissmutas after the experimental spinal cord injury in rats

Guo Wei-chu

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Abstract

Objective:To observe the active change of malonyldialdehyde (MDA)and superoxide dissmutas(SOD)contents in a series of intervals after acute spinal cord injury(SCI),and to study the free radical variation in secondary pathological damage of the spinal cord.Methods:The SCI model in rabbits were made with modified Allen’s method.The amount of MDA and SOD of spinal cord tissue were determined in the 12 h , 48 h , 3 d ,7 d,14 d and 21 d after injury.Results:The concentration of MDA significantly increased in the 24 h after SCI,reached the peak at the 7 d and then dropped down gradually.The activity of SOD significantly descended after SCI,was the lowest at 3 d and then return slightly.Conclusion:This study suggested that free radical plays an important role in the secondary pathological damage of SCI.

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Objective:To observe the active change of malonyldialdehyde (MDA)and superoxide dissmutas(SOD)contents in a series of intervals after acute spinal cord injury(SCI),and to study the free radical variation in secondary pathological damage of the spinal cord.Methods:The SCI model in rabbits were made with modified Allen’s method.The amount of MDA and SOD of spinal cord tissue were determined in the 12 h , 48 h , 3 d ,7 d,14 d and 21 d after injury.Results:The concentration of MDA significantly increased in the 24 h after SCI,reached the peak at the 7 d and then dropped down gradually.The activity of SOD significantly descended after SCI,was the lowest at 3 d and then return slightly.Conclusion:This study suggested that free radical plays an important role in the secondary pathological damage of SCI.

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Available abstract

Objective:To observe the active change of malonyldialdehyde (MDA)and superoxide dissmutas(SOD)contents in a series of intervals after acute spinal cord injury(SCI),and to study the free radical variation in secondary pathological damage of the spinal cord.Methods:The SCI model in rabbits were made with modified Allen’s method.The amount of MDA and SOD of spinal cord tissue were determined in the 12 h , 48 h , 3 d ,7 d,14 d and 21 d after injury.Results:The concentration of MDA significantly increased in the 24 h after SCI,reached the peak at the 7 d and then dropped down gradually.The activity of SOD significantly descended after SCI,was the lowest at 3 d and then return slightly.Conclusion:This study suggested that free radical plays an important role in the secondary pathological damage of SCI.

Key concepts: Medicine, Spinal cord, Spinal cord injury, Pathological, Superoxide dismutase, Superoxide, Anesthesia, Internal medicine

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Dynamical changes of free radical and superoxide dissmutas after the experimental spinal cord injury in rats — Research Paper | ScholarLens