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2007•Chinese Journal of Drug Application and MonitoringRequires access

The protective effects of ambroxol on hyperoxia and ventilator induced acute lung injury in rats

Yan Liu

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Abstract

Objective:To study the protective effects of ambroxol on hyperoxia and ventilator induced acute lung injury in rats. Methods:Thirty-six rats were randomly divided into three groups. W/D was counted. Neutrophils, TNF-α, IL-1β, and MIP-2 levels in BALF, MDA and SOD levels were assayed respectively.Results:The W/D ratio, neutrophils, TNF-α, IL-1β, and MIP-2 levels in BALF, MDA levels was lower in group C than group B, but the levels of SOD increased in group C than B.Conclusion:Ambroxol has obviously protective effects on hyperoxia and ventilator induced acute lung injury in rats.

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What this paper is about

Objective:To study the protective effects of ambroxol on hyperoxia and ventilator induced acute lung injury in rats. Methods:Thirty-six rats were randomly divided into three groups. W/D was counted. Neutrophils, TNF-α, IL-1β, and MIP-2 levels in BALF, MDA and SOD levels were assayed respectively.Results:The W/D ratio, neutrophils, TNF-α, IL-1β, and MIP-2 levels in BALF, MDA levels was lower in group C than group B, but the levels of SOD increased in group C than B.Conclusion:Ambroxol has obviously protective effects on hyperoxia and ventilator induced acute lung injury in rats.

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Available abstract

Objective:To study the protective effects of ambroxol on hyperoxia and ventilator induced acute lung injury in rats. Methods:Thirty-six rats were randomly divided into three groups. W/D was counted. Neutrophils, TNF-α, IL-1β, and MIP-2 levels in BALF, MDA and SOD levels were assayed respectively.Results:The W/D ratio, neutrophils, TNF-α, IL-1β, and MIP-2 levels in BALF, MDA levels was lower in group C than group B, but the levels of SOD increased in group C than B.Conclusion:Ambroxol has obviously protective effects on hyperoxia and ventilator induced acute lung injury in rats.

Key concepts: Medicine, Hyperoxia, Ambroxol, Lung, Anesthesia, Pharmacology, Internal medicine

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