Behavioural comparision on Fmr1 knockout mice at 30 days age in Morris water maze experiment

Objective To compare the behaviour defferences at 30 days age in Morris water maze experiment.Methods Fmr1 knockout mice were identified using the PCR technique,and Morris water maze experiment were used in the study.The data was analyzed with Multifactor Variance Analysis.Results ①Space navigation experiment from the first day to the third day,KO mice have no obviously difference with the WT mice in the Latency and number of crossing platform(P 0.05),but on the fourth day,there was a statistical significance(P 0.05);②Space search experiment.The four-week WT mice will stay longer than the other mice at the target quadrants;the four-week KO mice stay at the second quadrant longer.Conclusion Fmr1 knockout animals exhibited low ability of learning and memorizing in the Morris water maze task at 30 days Age.