Improvements of Allicinon Cerebral Ischemia-Reperfusion Oxidative Stress Injury in Rats

Objective To study the improving effects of allicin on cerebral ischemia-reperfusion injury in rats and explore the mechanism.Methods The 40 male Wistar rats were randomly divided into four groups.That is,control group(10),model group(10),low-dose group(10 mg/kg) and high dose group(20 mg/kg).Cerebral ischemia model was established in rats by improved Longa suture method through occluding the middle cerebral artery of the right side(MCAO).The reperfusion was operated 2 hours later and would last for 24 hours.The protective effects of allicin at different doses were evaluated by investigating mortality rate,neurological score and superoxide dismutase(SOD) activity.Results Compared with control group,the survival rate and neurological function score of model group were reduced,with SOD activity declined significantly(P0.05).Compared with model group,the survival rate of allicin group was dramatically increased,with neurological function score and SOD activity levels raised(P0.05),and there is a correspondence between the impact and dose.Conclusion Allicin has a good protective effect on acute cerebral ischemia-reperfusion injury and its mechanism may be related to increased activity of antioxidant enzymes and the improved state of oxidative stress.