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MORPHOLOGICAL CHANGES OF VENTRAL TEGMENTAL AREA DA NEURONS IN MORPHINE WITHDRAWAL RATS

SI Jingyu

Open publisher page 2 citations

Abstract

Objective: To study morphological changes of ventral tegmental area DA neurons in morphine natural withdrawal rats. Methods: Build up morphine natural withdrawal rats models, dye ventral tegmental area DA neurons by immunohistochemical method and analyze digital morphological changes of neurons by image processing techniques. Results: Compared with the normal saline (NS) treatment group, significant changes were observed in optical density (OD) (P0.05), area (P0.01), perimeter (P0.05), eccentricity (P0.05) and morphological index (MI) (P0.01) of short-run (2 d) withdrawal group and in MI (P0.05) of long-run (14 d) withdrawal group. There were significant differences in perimeter (P0.01), eccentricity (P0.05) and MI (P0.01) between short-run and long-run groups. Conclusion: Significant morphological changes have taken place in ventral tegmental area DA neurons in morphine natural withdrawal rats, and the changes become weaker as time goes on.

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What this paper is about

Objective: To study morphological changes of ventral tegmental area DA neurons in morphine natural withdrawal rats. Methods: Build up morphine natural withdrawal rats models, dye ventral tegmental area DA neurons by immunohistochemical method and analyze digital morphological changes of neurons by image processing techniques. Results: Compared with the normal saline (NS) treatment group, significant changes were observed in optical density (OD) (P0.05), area (P0.01), perimeter (P0.05), eccentricity (P0.05) and morphological index (MI) (P0.01) of short-run (2 d) withdrawal group and in MI (P0.05) of long-run (14 d) withdrawal group. There were significant differences in perimeter (P0.01), eccentricity (P0.05) and MI (P0.01) between short-run and long-run groups. Conclusion: Significant morphological changes have taken place in ventral tegmental area DA neurons in morphine natural withdrawal rats, and the changes become weaker as time goes on.

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Available abstract

Objective: To study morphological changes of ventral tegmental area DA neurons in morphine natural withdrawal rats. Methods: Build up morphine natural withdrawal rats models, dye ventral tegmental area DA neurons by immunohistochemical method and analyze digital morphological changes of neurons by image processing techniques. Results: Compared with the normal saline (NS) treatment group, significant changes were observed in optical density (OD) (P0.05), area (P0.01), perimeter (P0.05), eccentricity (P0.05) and morphological index (MI) (P0.01) of short-run (2 d) withdrawal group and in MI (P0.05) of long-run (14 d) withdrawal group. There were significant differences in perimeter (P0.01), eccentricity (P0.05) and MI (P0.01) between short-run and long-run groups. Conclusion: Significant morphological changes have taken place in ventral tegmental area DA neurons in morphine natural withdrawal rats, and the changes become weaker as time goes on.

Key concepts: Ventral tegmental area, Morphine, Saline, Internal medicine, Medicine, Dopamine, Dopaminergic

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MORPHOLOGICAL CHANGES OF VENTRAL TEGMENTAL AREA DA NEURONS IN MORPHINE WITHDRAWAL RATS — Research Paper | ScholarLens