2010•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access
Effect of Astragalus Membranaceus and Angelica Sinensis on the Nitric Oxide Content in Restenosis Rats
Yang Chang-chun
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Abstract
Objective To explore the effect of Astragalus Membranaceus and Angelica Sinensis on the nitric oxide content in restenosis rats.Methods The restenosis model was established by denuding the rat aorta endothelium with balloon catheter.The pathological features of the arterial wall and the changes of the nitric oxide content in plasma were observed in the model group after twenty-one days of treatment by Astragalus Membranaceus and Angelica Sinensis.Results In model group,the content of nitric oxide declined compared with control group,while the nitric oxide concentration in the plasma of all the Astragalus Membranaceusor Angelica Sinensis-treated groups was obviously higher than that of model group.More powerful effect could be observed after co-treatment by Astragalus Membranaceus and Angelica Sinensis together.Conclusion Astragalus Membranaceus and Angelica Sinensis can promote nitric oxide synthesis,which may be the mechanism in treatment of restenosis.