1994•PubMedRequires access

[Effects of amiodarone on ventricular refractory period caused by subthreshold electric stimulation].

Han-Ying Qiu, H Y Mao, LI Di-jun

Abstract

Effects of amiodarone (Ami) 25 mg.kg-1 iv on ventricular refractory period caused by subthreshold single or train stimulations were studied in rabbits. Before Ami i.v., the refractory period was prolonged by S1-St (P < 0.05, P < 0.01) and by Ss (St) which was intercalated to S1-S2 interval [S1-Ss (St)-S2 methods]. After Ami iv, the refractory period was shortened by S1-St (50 ms, 330 Hz, 6 V) (P < 0.01) and minimal inhibitory voltage of Ss was higher than that of pre-medication in different Ss-S2 intervals (20, 25 ms). These results suggested Ami may change the mode of terminating tachycardia by electric stimulation.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Refractory period, Amiodarone, Refractory (planetary science), Medicine, Effective refractory period, Stimulation, Ventricular tachycardia, Cardiology