The prognostic value of serum cardiac troponin-I in virus myocarditis

Objective:To investigate the prognostic value of serum cardiac troponin I(cTnI) in virus myocarditis.Method:The concentration of serum cTnI and CK,CK MB were simultaneously measured with monoclonal antibody to cTnI by ELISA method.38 from 52 cases were cTnI positive at first time.The 38 patients with acute virus myocarditis were divided into cTnI positive (n=18) and negative groups (n=20) while measured repeatedly in 3 months.Result:The recovery rate of arrhythmia and symptom improved rate were 33.3 % vs 70.0 % and 22.2 % vs 70.0 % respectively between the cTnI positive and negative groups and thereby showed significant statistically.38 ( 73.1 %) cases were cTnI positive while only 3( 5.8 %)showed CK MB positive among the total 52 cases from their first time test and there was significant difference of the positive rates between two methods(P 0.01 ).Serum negative conversion rate of the neutralizing antibody to the coxsackie B was lower ( 33.3 %)in the cTnI positive group compared with the 69.2 % in the cTnI negative group.Conclusion:cTnI may indicate the severity of inflammatory injury from the virus myocarditis and predict the prognosis of the illness.