The influences of midazolam on lidocaine-induced convulsion

Objective To observe the influences of midazolam on lidocaine -induced convulsion. MethodsLidocaine was administered intraperitoneally,and twenty minutes later,same doses of midazolam were administered intraperitoneally. To observe the convulsion latency,convulsion duration,incidence of no convulsion and mortality,and analyze the LD50 and the ED50 by sequential method in mice. ResultsThe convulsion latency of lidocaine-induced convulsion were extended by midazolam,the convulsion duration were shorten,and the incidence of no convulsion and mortality were reduction. The ED50 of lidocaine-induced convulsion were improved by midazolam(1.0 mg/kg); The LD50 were reduced by midazolam(2.0,5.0 mg/kg). ConclusionsMidazolam can antagonize the lidocaine-induced convulsion.