Reduced-intensity Bu/Cy+ATG as conditioning regimen for allogeneic hematopoietic stem cell transplantation in the patients with hematopoietic malignant disease

Objective To study the efficacy of allogeneic hematopoietic stem cell transplantation(Allo-hsct) treating hematopoietic malignant disease patients prepared with dose-reduced Bu/Cy+ATG conditioning regimen.Methods Eighteen patients who treated with dose-reduced Bu/Cy+ATG as conditioning regimen(mephalan:4 mg/(kg·d)×3,60 mg/(kg·d)×2,Me-CCNU 450 mg/(m2·d)×1,ATG 3 mg/(kg·d)×2,and graft-versus-host disease(GVHD) prophylaxis included cyclosporin A,MMF and MTX.Results All patients achieved full donor chimerism without graft failure.After a median follow-up period of 22 months(range,3-40 months),10 patients survived event-free,in the patients who treated with HSCT,the survival rate was 66.7%.Conclusion The reduced-intensity conditioning regimen using Bu/Cy+ATG is safe,effective and with less complications in HSCT for patients with hematological malignancies.