Expression and significance of CD_(44)V3,CD_(44)V6 and Ki-67 in breast cancer

Objective To explore the expression of CD44V3,CD44V6 and Ki-67 and their relation with biological behaviour of breast cancer.Methods The CD44V3,CD44V6 and Ki-67 were studied by tissue chip and immunohistochemistry in 60 cases of breast invasive ductal cancer and 20 cases of normal breast tissue.Results The positive rates of CD44V3,CD44V6 and Ki-67 were 41.7%,58.3% and 68.3% respectively,significantly higher than those in normal tissues(P0.05).There was significant correlation between CD44V6 and Ki-67 immunoreactivity and the histologic grading,lymph node metastasis(P0.05).There was significant correlation between CD44V6 and distant metastasis(P0.05).The positive correlation was observed between expression of CD44V6 and Ki-67(r=0.587,p0.01).Conclusion The expression of CD44V6 and Ki-67 is closely related to the tumor malignancy biological behaviour of breast cancer and its can predict the potential breast cancer cell metastasis.