Relationship between serum N-terminal probrain natriuretic peptide levels and short-term prognosis in patients with acute myocardial syndrome

Objective To evaluate the correlations of serum N-terminal probrain natriuretic peptide (NT-proBNP) levels and prognosis in patients with acute myocardial syndromes(ACS) during 1-year follow-up.Methods Serum NT-proBNP concentrations were measured by ELISA method within 48h after admission in 76 patients with ACS.The patients were followed up for 1 year and the main adverse cardiovascular events (MACE) were observed and recorded.Results Serum NT-proBNP levels was increased in patients with ACS compared with that in patients with stable angina and normal subjects(P0.05).The mean value of NT-proBNP concentrations in patients with ACS was 513.51±364.69pg/ml,the medium value was 421.5pg/ml.The incidence of MACE was increased in patients whose serum NT-proBNP concentration was higher than the mediam.Multivariate logistic regress analyisis revealed that NT-proBNP concentration was correlated with the incidence of MACE during follow-up independently(OR=3.66,95%CI:1.08-12.4 P=0.0368).Conclusion Serum NT-proBNP level is a indenpent predictor for 1-year MACE rate in patients with ACS.