2005•Traditional Chinese Drug Research and Clinical PharmacologyRequires access
Effect of Zhongfengkang on the Expression of AQP-4mRNA in Brain of Focal Cerebral Ischemia Rats
XU Huazhou
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Abstract
Objective To observe the effect of Zhongfengkang on the expression of Aquaporin 4 mRNA(AQP-4mRNA) in brain of focal cerebral ischemia rats. Methods The rat model of focal cerebral ischemia was established by inserting nylon thread.The dynamic changes of AQP-4 mRNA expression in the model group at 12th,24th,48th,72nd and 96th hour after cerebral ischemia were examined and the effect of Zhongfengkang on AQP-4 mRNA expression and cerebral edema at 48 th hour after cerebral ischemia was observed.Results At 12th hour after cerebral ischemia,the expression of AQP-4mRNA in the model group increased compared with the sham-operation group,and it arrived to the peak at 72th hour(P0.01);Compared with model group at 48th,the expression of AQP-4 mRNA and the brain edema in each treatment groups were decreased(P0.05 or P0.01).Conclusion By decreasing the expression of AQP-4 mRNA in brain of focal cerebral ischemia rats,Zhongfengkang could protect blood brain barrier and reduce cerebral edema.