Curative effect of rosuvastatin on cerebral infarction complicating carotid atherosclerosis

Objective To discuss the intervention effect of rosuvastatin on carotid atherosclerotic plaques in the patients with cerebral infarction. Methods The patients ( n =80 ) with cerebral infarction complicating carotid atherosclerosis were randomly divided into control group ( n =40 ) and observation group ( n =40 ) . The control group was given routine therapy for cerebral infarction and observation group, oral rosuvastatin ( 20 mg every night ) for 12 months besides of the routine therapy. The scores of carotid atherosclerotic plaques and level changes of blood fat and C-reactive protein ( CRP ) were observed in two groups before treatment, and after treatment for 3, 6 and 12 months. Results In observation group, the levels of total cholesterol ( TC ) , triglyceride ( TG ) , low-density lipoprotein-cholesterol ( LDL-C ) and CRP decreased significantly, and the level of highdensity lipoprotein-cholesterol ( HDL-C ) increased after treatment for 3, 6 and 12 months compared with those before treatment ( P 0.05 ) . The scores of atherosclerotic plaques were ( 3.89 ± 0.58 ) , ( 3.39 ± 0.42 ) and ( 3.21 ± 0.54 ) respectively in observation group after 3, 6 and 12 months, and ( 3.82 ± 0.67 ) , ( 3.88 ± 0.44 ) and ( 3.90 ± 0.36 ) respectively in control group. The scores showed an increasing trend in control group and showed a decreasing trend in observation group. The comparison between the scores after 6 months and those after 12 months had statistical difference ( P 0.05 ) in two groups. Conclusion Rosuvastatin has the improving effects on reducing lipid and dissolving plaques in the patients with cerebral infarction complicating carotid atherosclerosis.