The Correlation Between Compartmental Imbalance of Dendritic Cells and EASI Scores in Atopic Dermatitis

Objective To observe the change of two types of dendritic cells, mDC(CD11c+) and pDC(CD123+) in the peripheral blood of atopic dermatitis, and analysis it′s relationship on EASI scores. Methods Flow cytometry was applied to assess mDC(CD11c+) and pDC(CD123+) dendritic cell subsets in the peripheral blood of 20 patients with atopic dermatitis and 17 sex and age-matched human controls. The mDC(CD11c+)/pDC(CD123+) was caculated. Moreover, mDC(CD11c+)/pDC(CD123+) in patients with AD was campared to that in the controls, and the relationship between the mDC(CD11c+)/pDC(CD123+) and the EASI scores was evaluted, by Spearman rank test. Results mDC(CD11c+) cells was(0.179±0.095)% in patients with AD, this value was slightly, but significantly, higher than the(0.106±0.074)% in normal subjects(P0.05). Meanwhile, pDC(CD123+) cells were(0.112±0.069)% in patients with AD and(0.063±0.049)% in normal subjects, respectively.The differences were aslo significant between the two groups(P0.05).While there were no significant differences in the mDC(CD11c+)/pDC(CD123+), and the correlation between mDC(CD11c+)/pDC(CD123+) and EASI scores in the two groups. Conclusion Two types of dendritic cells mDC(CD11c+) and pDC(CD123+) cells in peripheral blood were increased simultaneously, which suggested that the results may contribute to the the pathogenesis of AD.