Clinical significance of combined determination of myocardial injury markers in neonates with hypoxic ischemic encephalopathy

Objective To study the clinical significance in diagnosing cardiac dysfunction by combined determination of myocardial injury markers in neonates with hypoxic ischemic encephalopathy(HIE).Methods The three myocardial injury markers,myoglobin(MYO),creatine kinase isoenzyme MB mass(CK-MB mass) and cardiac troponin I(cTnI)] of 148 patients with HIE neonates(35 severe,52 moderate and 61 mild) and 60 healthy subjects were determined,respectively,by microparticle chemiluminescent immunoassay.Results In the first day of birth,abnormal ratio of MYO was the highest in severe(82.86%),moderate(59.62%) and mild HIE(37.70%) than that of cTnI and CK-MB mass.The seroprevalence of cTnI and CK-MB mass were 68.57% and 74.29% for severe,36.54% and 38.46% for moderate and 4.92% and 8.20% for mild HIE(P0.05),respectively.In the third day of birth,the levels of MYO,CK-MB mass and cTnI of severe HIE group were the highest,and the moderate HIE group had secondary higher concentrations of MYO,CK-MB mass and cTnI.After the third day,the concentration of MYO in three HIE groups kept reducing but the CK-MB mass and cTnI increased to the peak and maintained above one week at higher levels.Conclusion The more severe cerebral injury the patients have,the more severe cardiac dysfunction they would suffer.Combined determination of MYO,CK-MB mass and cTnI can provide better efficiency of early diagnosis,risk and turnover assessment.