Effect of edaravone on neuropeptide Y and cerebral edema in patients with cerebral hemorrhage

Objective To analysis the effect of edaravone on neuropeptide Y (NPY) and cerebral edema in patients with cerebral hemorrhage. Methods Sixty-two patients with cerebral hemorrhage in our hospital were randomly divided into two groups. Patients in the study group (n=32) were treated with intravenous drip of edaravone based on routine treatment, while those in the control group (n=30) received routine treatment. The serum levels of NPY, the cerebral edema volume and the NIHSS score were investigated at admission, 7, 14 days after treatment. Results Seven days after treatment, the score of NIHSS was significantly lower than that at admission in the study group (P0.01). The levels of NPY in the study group were significantly lower than those in the control group at the same time points (P0.01); Fourteen days after treatment, the NIHSS scores started to decrease significantly (P0.01), but the decrease was significantly less profound than that in the study group (P0.05). The levels of NPY were significantly lowered in both the two groups, but the changes in the study group was more profound (P0.01). The cerebral edema volume was significantly lower in the study group than the control group (P0.01). Conclusion Edaravone can reduce the level of NPY, improve the neurological function and prevent secondary brain edema.