2005•Chinese Journal of Clinical Laboratory ScienceRequires access
Detection for inducible clindamycin-resistant of staphylococcus isolates and analysis of resistance
Huanle Liu, Tieli Zhou
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Abstract
Objective To investigate the frequency of inducible clindamycin-resistant of staphylococcus isolates in the local district.Methods The susceptibilities of erythromycin and clindamycin for staphylococcus were examined by Kirby-Bauer disc agar diffusion test and the inducible clindamycin-resistance was detected by D-test.Results Of 61 erythromycin-resistant Staphylococcus aureu isolates,40 were demonstrated to be resistant to clindamycin,while 21 showed susceptible to clindamycin,among them 8 were inducible clindamycin-resistant isolates.Of 106 erythromycin-resistant coagulase-negative staphylococcus(CNS) isolates,62 were demonstrated to be resistant to clindamycin,while 44 showed susceptible to clindamycin,among them 27 were inducible resistant isolates.Conclusion The percentage of inducible clindamycin-resistance was 53.8% (35/65) in clindamycin-susceptible staphylococcus isolates.The results indicated that D-test should be performed in clindamycin-susceptible isolates which were failing in clinical therapy by using clindamycin for staphylococcal infection.