Clinical research on value of dobutamine stress echocardiography combined with variation of diastolic function indexes in strain rate imaging in diagnosis of coronary artery disease

Objective To investigate the clinical value of dobutamine stress echocardiography(DSE) combined with variation of diastolic function indexes of strain rate imaging(SRI) in the diagnosis of coronary artery disease(CAD). Methods Twenty-eight patients with suspected CAD received DSE and analysis diastolic function indexes in strain rate imaging, before selective coronary angiography(SCA). Using SCA results as the golden standard of the diagnosis, the diagnostic sensitivity, specificity and accuracy rate of conventional eye-view and DSE-SRI were compared. Results The peak strain rate during early diastolic(SRe) of myocardial segments perfused by stenotic coronary artery were lower and the time of the beginning of diastole(Td) were longer than that of segments perfused by normal coronary artery during high dose DSE. For conventional DSE eye-view method, the diagnosis of sensitivity,specificity and accurary rate were 84%,86% and 86%, while that of DSE-SRe(Td) were 91%(93%),87%(85%) and 89%(90%), respectively. Conclusions DSE combined with variation of diastolic function indexes of SRI can improve the noninvasive diagnostic sensitivity of abnormal diastole of CAD, as well as quantitative analysis of the diastolic condition of CAD patients under DSE.