2009•Journal of Chinese Practical Diagnosis and TherapyRequires access
Effects of carvedilol on TGF-β_1 and I type collagen after acute myocardial infarction in rats
Jian Liguo
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Abstract
Objective To observe the effects of carvedilol on TGF-β1 and Ⅰtype collagen after acute myocardial infarction in rats.Methods Rats surviving 24 hours after acute myocardial infarction induced by left anterior descending branch ligation were randomly divided into carvedilol group,control group and sham-operation group.Carvedilol group was given carvedilol 10 mg/(kg·d).Control and sham-operation group were given saline 15 mL/(kg·d).The hemodynamic and ventricular remodeling index,the expression of TGF-β1 and Ⅰtype collagen were analyzed by the end of the 4th week.Results By the end of the 4th week,the left ventricular weight,the heart weight index and the left ventricular weight index in carvedilol group were elevated compared with those of the sham-operation group(all P0.05).While after carvedilol treatment,the indexes mentioned above decreased significantly in carvedilol group compared with control group(all P0.05).Compared with control group,the indexes of hemodynamic and ventricular remodeling were improved in carvedilol group(all P0.05).Conclusion Carvedilol improves ventricular remodeling after acute myocardial infarction in rats via inhibiting the expression of TGF-β1 and Ⅰtype collagen.