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Changes of Cathepsin B Expression in Rats after Cerebral Ischemia-Reperfusion

Chen Ben-yang

Abstract

Objective:To investigate the changes of Cathepsin B expression in different time point in rat after cerebral ischemia-reperfusion. Methods:Sixty SD rats were divided into normal group (n=10), sham-operated group (n=10) and cerebral ischemia reperfusion model group (model group, n=40), the expression of the protein and mRNA of Cathepsin B were respectively evaluated by methods of immunohistochemistry and RT-PCR. Results:compared with normal group and sham-operated group , The expression level of the protein and mRNA of Cathepsin B in the rats of model group increased significantly 1 hour and got to their peak 6h , kept a high level on 48h. Conclusions:The expression of Cathepsin B after ischemia-reperfusion is high and plays an important role in neuronal apoptosis.

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Key concepts: Cathepsin B, Ischemia, Immunohistochemistry, Messenger RNA, Group A, Cathepsin D, Apoptosis, Medicine