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2003•Acta Nutrimenta SinicaRequires access

EFFECT OF CURCUMIN ON PROLIFERATION AND APOPTOSIS OF TK6 CELLS

Lishi Zhang

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Abstract

Objective: To explore the effect of curcumin on proliferation and apoptosis of TK6 human diploid lymphoblastoid cells.Methods: MTT colorometric assay, 3H-TdR incorporation, cell cycle analysis were used to evaluate the effect on proliferation, and morphology microstructure. Flow cytometry was used to detect the effect on apoptosis induction on TK6 cell.Results: Curcumin could inhibit proliferation by blocking transition from G0/G1 to S phase, induce apoptosis in TK6 cells. The effective dose for proliferation inhibition and apoptosis induction is 20 μmol/L.Conclusion: Apoptosis induction is one of important mechanisms for anti-mutagenic, anti-tumor action of curcumin.

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What this paper is about

Objective: To explore the effect of curcumin on proliferation and apoptosis of TK6 human diploid lymphoblastoid cells.Methods: MTT colorometric assay, 3H-TdR incorporation, cell cycle analysis were used to evaluate the effect on proliferation, and morphology microstructure. Flow cytometry was used to detect the effect on apoptosis induction on TK6 cell.Results: Curcumin could inhibit proliferation by blocking transition from G0/G1 to S phase, induce apoptosis in TK6 cells. The effective dose for proliferation inhibition and apoptosis induction is 20 μmol/L.Conclusion: Apoptosis induction is one of important mechanisms for anti-mutagenic, anti-tumor action of curcumin.

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Available abstract

Objective: To explore the effect of curcumin on proliferation and apoptosis of TK6 human diploid lymphoblastoid cells.Methods: MTT colorometric assay, 3H-TdR incorporation, cell cycle analysis were used to evaluate the effect on proliferation, and morphology microstructure. Flow cytometry was used to detect the effect on apoptosis induction on TK6 cell.Results: Curcumin could inhibit proliferation by blocking transition from G0/G1 to S phase, induce apoptosis in TK6 cells. The effective dose for proliferation inhibition and apoptosis induction is 20 μmol/L.Conclusion: Apoptosis induction is one of important mechanisms for anti-mutagenic, anti-tumor action of curcumin.

Key concepts: Curcumin, Apoptosis, Flow cytometry, Cell growth, Cell cycle, Chemistry, MTT assay, Cell biology

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