The changes and clinical significance of neuropeptide Y and neuron-specific enolase levels in children with convulsibility diseases

Objective To explore the changes and clinical significance of neuropeptide Y(NPY) and neuron-specific enolase(NSE) levels in children with convulsibility diseases.Methods Six-two children with convulsibility diseases were selected as convulsion group, and 20 healthy children served as normal control group. The blood samples were collected within the first 24 hours after seizure. The levels of NPY were measured by radioimmunoassay,and the NSE detected by enzyme-linked immunosorbent assay.Results The levels of blood NPY and NSE in convulsion group (including viral encephalitis,epilepsy and febrile convulsion) were significantly higher than those in normal control group(P0.01).The levels of NSE in children with serious convulsion group were significantly higher than those in common convulsion group(P0.01),and the levels of NPY in serious convulsion group were significantly lower than those in common convulsion group(P0.01).The level of NPY was negatively correlated with that of NSE in children with convulsion at acute stage(r=-0.74,P0.01).Conclusion The levels of blood NPY and NSE in children with convulsibility diseases are significantly higher after seizure,which has a close correlation with the severity of brain injury and may serve as the objective indicators in the early prediction of the degree of brain injury.