Study of late course three dimensional-conformal radiotherapy combined with chemotherapy for 29 cases with recurrent rectal cancer.

Objective To study the effect of recurrent rectal cancer teated by three dimensional-conformal radiotherapy(3D-CRT) combined with chemotherapy(CT).Methods Total of 58 patients with recurrent rectal cancer were divided randomly into two groups:29 cases received CT plus 3D-CRT(3D-CRT group);29 cases received CT plus conventional radiotherapy(control group).A total tumor dose of 40 Gy by three-field from the same center for conventional radiotherapy in the first course;followed in the 3D-CRT group by 3D-CRT to DT65~70Gy,in the control group by two-field for conventional radiotherapy to DT55~60Gy.Two goups were all treated one course by FP precept in the first week,and then 3~5courses were given after the end of radiotherapy.Results The 3-year local regional control rates for 3D-CRT group and control group were 65.5%,48.3%(P0.05);the 1-and 2-year survival rates for two groups were 89.3%,58.6% and 82.8%,41.3%(P0.05),middle survival time were 30 and 21 months.The side effects were similar in the two groups.Conclusion 3D-CRT plus CT may significantly improve the effect of the treatmentin in recurrent rectal cancer patients.