The clinical significance of the five immunologic parameters for determining pathological changes in patients with nephritis or nephropathy syndrome

Objective To study the clinical significance of 5 immunologic parameters in patients with nephritis or nephrotic syndrome. Methods 143 blood specimens from 45 normal controls, 56 nephritis patients and 42 patients with nephrotic syndrome were studied to determine the contents of SC5b-9, CIC and CH50 and the titers of ANA and AdsDNA antibodies by using PEG precipitation reaction, hemolytic assay, sandwich ELISA and Dot-IGSS respectively. Results The detectability rate of SC5b-9 was the highest among these parameters and the sensitivity of the test for SC5b-9 was higher than that for CH50. Moreover, the titers of ANA and AdsDNA antibodies in patients with nephritis syndrome were higher than in those with nephrotic syndrome. Conclusion The parameters mentioned above are of certain value in helping understand the pathologic changes and differentiate nephritis from nephrotic syndrome.