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2002•Chinese Journal of New Drugs and Clinical RemediesRequires access

Paroxetine vs imipramine in treatment of post-stroke depressive disorder

Zhang Liu

Open publisher page 4 citations

Abstract

AIM:To compare the effects and adverse reactions of paroxetine and imipramine in treating patients with post stroke depressive disorder. METHODS: One hundred and twenty one patients with post stroke depressive disorder were randomly divided into two groups; 61 patients (M 35, F 26; age 62 a± s 10 a) were treated with paroxetine first dose 10 mg, then 20 mg, po , qd, for 6 wk, and another 60 patients (M 33, F 27; age 63 a±11 a) were treated with imipramine d 1 2 25 mg, d 3 5 50 mg and from d 6 on 75 mg, po , bid, for 6 wk. RESULTS: The total clinical effect rates was 84 % in paraxetine group and 82 % in imipramine group ( P 0.05). The adverse reactions in imipramine group was higher than that in praroxetine group. CONCLUSION: Paroxetine may be avaliable in the treatment of post stroke depressive disorder.

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AIM:To compare the effects and adverse reactions of paroxetine and imipramine in treating patients with post stroke depressive disorder. METHODS: One hundred and twenty one patients with post stroke depressive disorder were randomly divided into two groups; 61 patients (M 35, F 26; age 62 a± s 10 a) were treated with paroxetine first dose 10 mg, then 20 mg, po , qd, for 6 wk, and another 60 patients (M 33, F 27; age 63 a±11 a) were treated with imipramine d 1 2 25 mg, d 3 5 50 mg and from d 6 on 75 mg, po , bid, for 6 wk. RESULTS: The total clinical effect rates was 84 % in paraxetine group and 82 % in imipramine group ( P 0.05). The adverse reactions in imipramine group was higher than that in praroxetine group. CONCLUSION: Paroxetine may be avaliable in the treatment of post stroke depressive disorder.

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Available abstract

AIM:To compare the effects and adverse reactions of paroxetine and imipramine in treating patients with post stroke depressive disorder. METHODS: One hundred and twenty one patients with post stroke depressive disorder were randomly divided into two groups; 61 patients (M 35, F 26; age 62 a± s 10 a) were treated with paroxetine first dose 10 mg, then 20 mg, po , qd, for 6 wk, and another 60 patients (M 33, F 27; age 63 a±11 a) were treated with imipramine d 1 2 25 mg, d 3 5 50 mg and from d 6 on 75 mg, po , bid, for 6 wk. RESULTS: The total clinical effect rates was 84 % in paraxetine group and 82 % in imipramine group ( P 0.05). The adverse reactions in imipramine group was higher than that in praroxetine group. CONCLUSION: Paroxetine may be avaliable in the treatment of post stroke depressive disorder.

Key concepts: Imipramine, Paroxetine, Major depressive disorder, Adverse effect, Stroke (engine), Medicine, Internal medicine, Anesthesia

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