Comparison of Multi-Biological Toxicities between Chromium Exposed Caenorhabditis elegans and Their Progeny

Multi-biological toxicities in chromium exposed animals and their progeny were analyzed using model organism Caenorhabditis elegans. Endpoints of development, reproduction, locomotion behavior, behavioral plasticity and lifespan were selected for the assay of multiple toxicities from chromium exposure. Our data suggested that the chromium exposure could result in multi-biological defects of phenotypes and behaviors. Low-concentration(2.5μmol·L-1) chromium exposure caused severe defects of development, reproduction and lifespan. High-concentration(75 and 200μmol·L-1)chromium exposure could further result in severe defects of locomotion behaviors and behavioral plasticity. Moreover, most of these toxicities caused by high-concentration chromium exposure could be transferred from exposed animals to their progeny. In progeny animals, the phenotypic and behavioral defects could be only partially or very slightly rescued. Therefore, the multi-biological defects caused by chromium exposure could be largely transferred from exposed animals to their progeny in C. elegans.