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2005•Chinese Clinical OncologyRequires access

The effect of Herceptin on the growth of nasopharyngeal carcinoma cell lines with HER-2/neu gene overexpression

HE Li-ron

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Abstract

Objective:To study the effect and mechanism of Herceptin on the growth of nasopharyngeal carcinoma (NPC) cell lines with HER-2/neu gene overexpression.Methods:The effect of Herceptin on the growth of NPC CNE-2Z and CNE-2 cell lines in vitro was tested by MTT and ~3H-TdR incorporation, and the effect of the cell growth and cell cycle and apoptosis on NPC CNE-2Z cell line was assayed by flow cytometer.Results:Herceptin could inhibit the growth of CNE-2Z cell line, and induce cell apoptosis index to increase.Conclusion:Herceptin inhibited the growth of CNE-2Z cell lines with HER-2/neu gene overexpression, and induced cell (apoptosis.)

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What this paper is about

Objective:To study the effect and mechanism of Herceptin on the growth of nasopharyngeal carcinoma (NPC) cell lines with HER-2/neu gene overexpression.Methods:The effect of Herceptin on the growth of NPC CNE-2Z and CNE-2 cell lines in vitro was tested by MTT and ~3H-TdR incorporation, and the effect of the cell growth and cell cycle and apoptosis on NPC CNE-2Z cell line was assayed by flow cytometer.Results:Herceptin could inhibit the growth of CNE-2Z cell line, and induce cell apoptosis index to increase.Conclusion:Herceptin inhibited the growth of CNE-2Z cell lines with HER-2/neu gene overexpression, and induced cell (apoptosis.)

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Available abstract

Objective:To study the effect and mechanism of Herceptin on the growth of nasopharyngeal carcinoma (NPC) cell lines with HER-2/neu gene overexpression.Methods:The effect of Herceptin on the growth of NPC CNE-2Z and CNE-2 cell lines in vitro was tested by MTT and ~3H-TdR incorporation, and the effect of the cell growth and cell cycle and apoptosis on NPC CNE-2Z cell line was assayed by flow cytometer.Results:Herceptin could inhibit the growth of CNE-2Z cell line, and induce cell apoptosis index to increase.Conclusion:Herceptin inhibited the growth of CNE-2Z cell lines with HER-2/neu gene overexpression, and induced cell (apoptosis.)

Key concepts: Nasopharyngeal carcinoma, Cell culture, Apoptosis, Cell growth, Growth inhibition, Cancer research, Cell, Cell cycle

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The effect of Herceptin on the growth of nasopharyngeal carcinoma cell lines with HER-2/neu gene overexpression — Research Paper | ScholarLens