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2006•Shanxi yiyao zazhiRequires access

Expression of MMP-2 and TIMP-2 in endometriosis

Chen Xiang-we

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Abstract

Objective To investigate the expression of MMP-2 and TIMP-2 in affected tissue from women with and without endometriosis for exploring the role of MMP-2 and TIMP-2 in endometriosis.Methods Expression of MMP-2 and TIMP-2mRNA was evaluated by in situ hybridization.Results ①Both ectopic and entopic endometrium expressed higher levels of MMP-2 and lower levels of TIMP-2 than endometrium from normal women.Also,ectopic endometrium expressed higher levels of MMP-2 and lower level of TIMP-2 than entopic endometrium from endometriosis patients.The higher levels of MMP-2 and the lower levels of TIMP-2 expressed in stages Ⅲ/Ⅳ than in stages Ⅰ/Ⅱ.② There was a significantly negative correlation between expression of MMP-2 and TIMP-2 in normal endometrium.Conclusion MMP-2 and TIMP-2 play an important role in the progression of endometriosis.

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What this paper is about

Objective To investigate the expression of MMP-2 and TIMP-2 in affected tissue from women with and without endometriosis for exploring the role of MMP-2 and TIMP-2 in endometriosis.Methods Expression of MMP-2 and TIMP-2mRNA was evaluated by in situ hybridization.Results ①Both ectopic and entopic endometrium expressed higher levels of MMP-2 and lower levels of TIMP-2 than endometrium from normal women.Also,ectopic endometrium expressed higher levels of MMP-2 and lower level of TIMP-2 than entopic endometrium from endometriosis patients.The higher levels of MMP-2 and the lower levels of TIMP-2 expressed in stages Ⅲ/Ⅳ than in stages Ⅰ/Ⅱ.② There was a significantly negative correlation between expression of MMP-2 and TIMP-2 in normal endometrium.Conclusion MMP-2 and TIMP-2 play an important role in the progression of endometriosis.

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Available abstract

Objective To investigate the expression of MMP-2 and TIMP-2 in affected tissue from women with and without endometriosis for exploring the role of MMP-2 and TIMP-2 in endometriosis.Methods Expression of MMP-2 and TIMP-2mRNA was evaluated by in situ hybridization.Results ①Both ectopic and entopic endometrium expressed higher levels of MMP-2 and lower levels of TIMP-2 than endometrium from normal women.Also,ectopic endometrium expressed higher levels of MMP-2 and lower level of TIMP-2 than entopic endometrium from endometriosis patients.The higher levels of MMP-2 and the lower levels of TIMP-2 expressed in stages Ⅲ/Ⅳ than in stages Ⅰ/Ⅱ.② There was a significantly negative correlation between expression of MMP-2 and TIMP-2 in normal endometrium.Conclusion MMP-2 and TIMP-2 play an important role in the progression of endometriosis.

Key concepts: Endometriosis, Matrix metalloproteinase, Endometrium, Medicine, In situ hybridization, Internal medicine, Endocrinology, Gynecology

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