Application of Tirofiban in Percutaneous Coronary Intervention for Actuemyocardial Infarction Patients

Objective To evaluate the safety and efficacy of tirofiban in percutaneous coronary interention(PCI) for acute myocardial infarction(AMI).Methods 80 AMI patients were randomly divided into two groups:the tirofiban group(n=34) and the control group(n=30).All the individuals were performed PCI within 12 hours after onest of AMI.All the test group individuals were injected Tirofiban(10mg)into the infarction related artery(IRA)during PCI and intravenously adminstered Tirofiban 36 hours(0.15μg/kg.min) after PCI.The control group only receive routine intravenous heparin therapy before and during PCI.The post operation TIMI blood flow,bleeding events and major adverse cardiac events were observed in the 2 groups.Results In tirofiban group,the occurance of slow-reflow and The major adverse cardiac events were lower than those in control group,The occurance of bleeding complication In Tirofiban group was the same as those in control group,there was no significant difference in both groups.Conclusion Application of Tiorfiban intracoronary injection during primary PCIin patients with AMI was safe and effective,which may reduce the occurrence of the major adverse cardiac events,and improve TIMI flow of IRA in patients with AMI during primary PCI.