2010•Chinese Journal of Health Laboratory TechnologyRequires access

The clinical application of serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen detection In Patients with rheumatoid arthritis

Yuning Liao

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Abstract

Objective:To study the Clinical Application of Serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen(ICTP) Detection In Patients With Rheumatoid Arthritis(RA).Methods: Serum level of ICTP was measured by ELISA in 86 RA and 41 non-RA patients and 40 normal controls.Results: The serum levels of ICTP in the RA and non-RA patients were remarkably higher than that in the normal controls(P0.05);The serum level and positive rate of ICTP in the RA was remarkably higher than that in non-RA patients(P0.05).Conclusion: The serum level of ICTP can reflect the degree of joint destruction and the progression of the disease in patients with RA.

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Objective:To study the Clinical Application of Serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen(ICTP) Detection In Patients With Rheumatoid Arthritis(RA).Methods: Serum level of ICTP was measured by ELISA in 86 RA and 41 non-RA patients and 40 normal controls.Results: The serum levels of ICTP in the RA and non-RA patients were remarkably higher than that in the normal controls(P0.05);The serum level and positive rate of ICTP in the RA was remarkably higher than that in non-RA patients(P0.05).Conclusion: The serum level of ICTP can reflect the degree of joint destruction and the progression of the disease in patients with RA.

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Available abstract

Objective:To study the Clinical Application of Serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen(ICTP) Detection In Patients With Rheumatoid Arthritis(RA).Methods: Serum level of ICTP was measured by ELISA in 86 RA and 41 non-RA patients and 40 normal controls.Results: The serum levels of ICTP in the RA and non-RA patients were remarkably higher than that in the normal controls(P0.05);The serum level and positive rate of ICTP in the RA was remarkably higher than that in non-RA patients(P0.05).Conclusion: The serum level of ICTP can reflect the degree of joint destruction and the progression of the disease in patients with RA.

Key concepts: Pyridinoline, N-terminal telopeptide, Rheumatoid arthritis, Medicine, Internal medicine, Type I collagen, Gastroenterology, Endocrinology

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