Combined Treatment of Condyloma Acuminatum with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy and Microwave Therapy

Objective Comparison of clinical effects of 5-aminolevulinic acid photodynamic therapy and microwave therapy on condyloma acuminatum. Methods Altogether 90 patients of condyloma acuminatum were divided randomly into 3 groups. A group consists of 20 patients with condyloma acuminatum on special sites(urethral mouth,tie-back or cervical area),who were only given ALA-PDT therapy. The rest 70 patients were further divided into two groups,each having 35 patients,and were given ALA-PDT and microwave therapy jointly(B Group) and sole microwave treatment(C Group) respectively. ALA-PDT therapy was conducted once a week,3 times for a course. As to microwave therapy,depending on wart size,warts were removed through one or more treatments. The curative effect was evaluated at the end of the first week after the treatment,and the recurrence rate was obtained via 3 months' follow-up. Results For patients having condyloma acuminatum on special sites,the clearance rate stood at 95. 2% at the end of the first week after being given ALA-PDT alone with a total relapse rate of 10. 0%. Despite of a clearance rate of 100. 0% being observed in both the joint treatment group and the single microwave treatment group at the end of the first week after the treatment,the total relapse rates of the groups were 8. 6% and 28. 6% respectively,indicating a difference that is statistically significant(P 0. 05). Conclusions ALA-PDT in combination with microwave is effective in treating condyloma acuminatum with a low relapse rate. ALAPDT works well with warts on special sites,and is widely used in clinically.