[Clinical analysis of tubulointerstitial lesions in IgA nephropathy].

OBJECTIVE: To analyze the characteristics of tubulointerstitial lesions (TIL) in IgA nephropathy (IgAN). METHODS: The pathologic and clinical materials of 609 IgAN patients were analyzed. RESULTS: (1) Prevalence characteristics of TIL: Among all the patients, these with mild TIL accounted for 47.1%, moderate TIL 21.7%, severe TIL was about 16.6% and these without TIL 14.6%. (2) Relationship between TIL and the clinical findings: With increase of the severity of TIL, hypertension became worse and the level of proteinuria increased gradually. On the contrary, serum albumin decreased and renal function degraded. (3) Relationship between TIL and the pathologic findings: With increase of the severity of TIL, the scores of vascular lesion, total glomerular lesion, hypercellularity and glomerulosclerosis increased gradually. Moreover, when the glomerular lesion and vascular lesion became worse, the severity of TIL also increased. The relationship with the crescents was different, the score of the presence of crescents was highest when TIL was moderate in severity; it would not increase when TIL was severe. CONCLUSION: With the increase of the severity of TIL, the condition of IgAN patients became worse. TIL may be one of the key factors for the prognosis of IgAN. TIL is closely related to the severity of glomerular and vascular lesions, and these lesions may further lead to the development of TIL.