Significance of the Detection of D-Dimer,Fibrinogen and Antithrombin-III in the Patients with Type II Diabetic Nephropathy

Objective: To explore the changes of D-Dimer,fibrinogen and antithrombin-Ⅲ(AT-Ⅲ) in the patients with type Ⅱ diabetic nephropathy(DN) and its clinical significance.Methods: Automatic coagulation analyzer TOP was used to detect the D-Dimer,fibrinogen and antithrombin-Ⅲ(AT-Ⅲ),in 121 type Ⅱdiabetes mellitus patients and 36 controls.The DM groups were divided into non-albuminuria group(UAE30 mg/24 h,62 patients) and micro-albuminuria group(UAE: 30~300 mg/24h,59patients).Results:Compared with controls,D-Dimer and fibrinogen increased significantly in non-albuminuria group(P0.05).For the activity of AT-Ⅲ,there was no difference between the non-albuminuria group and the control group(P0.05).D-Dimer and fibrinogen increased significantly(P0.05) in micro-albuminuria group,compared with controls and the non-albuminuria.AT-III decreased significantly(P0.05) in micro-albuminuria group,compared with the non-albuminuria.Conclusions: Detection of D-Dimer,fibrinogen and antithrombin-III(AT-Ⅲ) in the patients with type Ⅱ diabetic,may have certain significance in monitoring early prevention of DN.