Clinical research of detecting CK19 in lymph nodes micrometastases of early-stage cervical cancer patients

Objective: To evaluate the significance of cytokeratin 19(CK19) expression of pelvic lymph nodes in patients with earlystage cervical cancer without lymph node metastasis by immunohistochemistry. Methods:32 patients with postoperative recurrences and distant metastases from 275 selected patients was patients group and other patients without recurrences and metastases was control group according to the treatment,age,histological type,clinical stage and tumor maximum diameter. CK19 were detected of lymph node paraffin sections in selected patients by immunohistochemistry. Results: ①11 lymph nodes from 477 lymph nodes in patients group were CK19 positive (2.3%) in which CK19 positive rates was 25%; CK19 positive rate of 32 patients in the control group was 0; the difference between two groups was statistically significant.②CK19 expression,the pathological type and tissue differential degree were correlated(P0.05).③Micrometastases,postoperative recurrence and metastasis were correlated(P0.05). Conclusion: Compared to traditional pathologichistology,the immunohistochemical stainning detecting CK19 can improve the detection rate of micrometastases in cervical cancer. Confirmed by this study, micrometastases and postoperative recurrence, metastasis were correlated.