Analysis of using cerebrospinal fluid procalcitonin level to diagnose intracranial infection after craniotomy

OBJECTIVE To explore the diagnostic accuracy of cerebrospinal fluid procalcitonin(PCT)level in intracranial infection after craniotomy,so as to provide a quick treatment for patients.METHODS According to diagnostic criteria of intracranial infection in hospital,30post-craniotomy patients with intracranial infection after craniotomy from May 2011to May 2013were selected as infected group and 30post-craniotomy patients without intracranial infection after craniotomy from May 2011to May 2013 were selected as disinfected group.Every patient′s serum and cerebrospinal fluid were taken to test the level of serum WBC,PCT and CSF proteins,WBC,PCT and all data were analyzed by SPSS13.0software.RESULTS Serum PCT and CSF proteins,WBC,PCT values in the infected group were significantly improved and higher than those in the disinfected group(P0.05).The positive biomarkers of serum WBC was 10×109/L,when the sensitivity,specificity and accuracy were 72.46%,62.13%and 69.90%.The positive biomarkers of serum PCT was 100ng/L,when the sensitivity,specificity and accuracy were 67.55%,83.19%and 79.59%.CONCLUSIONCSF PCT has higher sensitivity and specificity than others and had higher diagnostic accuracy in diagnosis of intracranial infection after craniotomy.