2011•Zhongguo yaolixue tongbaoRequires access

Protective effects of Liuweiwulingpian on hepatic fibrosis induced by carbon tetrachloride in rats

Quancheng Kan

Abstract

Aim To study the protective effects of Liuweiwulingpian against hepatic fibrosis induced by carbon tetrachloride(CCl4) in rats.Methods The rats were given to CCl4-vegetable oil by abdominal injection for 4 weeks,then the successful model rats were randomly divided into 5 groups,with 12 rats in each group,respectively: the model group,the positive drug group,the low dose Liuweiwulingpian group(4 g·kg-1),the middle dose Liuweiwulingpian group(8 g·kg-1),the high dose Liuweiwulingpian group(16 g·kg-1).ALT,AST,HA,LN,HyP in serum and SOD,MDA in the liver were determined.Moreover,the morphological changes of rat liver tissue were observed by Masson′s trichrom stain.Results Compared with the model group,the level of serum ALT,AST,HA,LN,HyP in Liuweiwulingpian group decreased significantly(P0.05);the content of MDA vastly decreased(P0.05) and the content of SOD and GSH(P0.05) increased.Conclusion Liuweiwulingpian can afford a better protective effect against carbon tetrachloride-induced hepatic damage in rats.

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Key concepts: Carbon tetrachloride, CCL4, Chemistry, Hepatic fibrosis, Internal medicine, Tetrachloride, Endocrinology, Liver tissue