The role of tumor necrosis facter α in neurogenetic pulmonary edema

Objective To study the role of tumor necrosis facter α(TNF-α) in neurogenetic pulmonary edema. Methods The levels of TNF-α in plasma were measured in rats which suffered from diffuse brain injury at different time on marmarous model .Results Pulmonary interstitial tissue was increasingly broadened and leucocyte infiltration dominated by neutrophils in 1 h , 3 h and 6 h . From 24 h to 48 h , bleeding ,swelling and protein effusion in pulmonary alveoli were observed ; The levels of TNF-α in plasma in 1 h of brain injury group was higher than in the controls (P0.05) ; TNF-α in 6 h reached top that is significantly elevated comparing with the controls (P0.01). Conclusions The inflammatory injury caused by TNF-α is one of the most important machanisms of neurogenetic pulmonary edema .