Cerebral ischemic tolerance and expression of IL-17 in rats

Objective To observe the effect of focal cerebral ischemic pretreatment on the expression of interleukin-17(IL-17) and to investigate the relationship between IL-17 and cerebral ischemic tolerance in rats.MethodsMiddle cerebral artery occlusion(MCAO) was used to establish the model of focal cerebral ischemic tolerance.IL-17 expression and brain infarction volume,pathological morphological change were determined with immunohistochemistry.ResultsInfarction volumes in the ischemia group were significantly larger than those in the tolerance group.Significant differences in the mean area density and mean gray scale of IL-17 positive cells were found between the two groups(P0.05).The positive expression of IL-17 was correlated with the infarction volume(P0.05).ConclusionFocal cerebral ischemic pretreatment can induce ischemic tolerance and provide protective function for the following cerebral infarction obviously.IL-17 may be associated with the occurrence and development of cerebral ischemic tolerance.