Advance in the research on several nuclear receptors related to bile acid metabolism

Bile acids are the major end-products of cholesterol metabolism and complex physiological molecules that are essential for solubilization, absorption, and transportation of dietary lipids in the liver and intestine. Many nuclear receptors coordinate transcription of bile acid homeostasis such as farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, liver X receptor, and peroxisome proliferator-activated receptor. Studies on nuclear receptors related to bile acid metabolism are important to know the regulation mechanism of bile acid metabolism and direct clinical drug usage.