2007•Zhongguo shiyong neike zazhiRequires access
Expression of PPAR-γ in a rabbit model of atherosclerosis and the effect of atorvastatin
Qin Lin
Open publisher page 0 citations
Abstract
Objective To investigate the expression of peroxisome proliferator-activated receptor-γ(PPAR-γ)in a rabbit model of atherosclerosis,and the effect of atorvastatin.Methods Twenty-four male Japanese rabbits were separated into 3 groups(8 in each group),which were high-fat diet group(group A),high-fat plus atorvastatin group(group B)and normal diet group(group C).All the animals were sacrificed after 16 weeks.The expression of PPAR-γ was detected with immunohistochemical assay,and plasma lipid with automatic biochemical analysis device.Results The expression of PPAR-γ were,respectively,high-fat diet group(11.23±1.21)%,high-fat plus atorvastatin diet group(11.05±1.02)% and normal diet group(7.68±1.04)%.Between group A and B there wasn’t any significant difference(P 0.05).Meanwhile,they both had significant differences compared with group C(P 0.01).TC and LDL expression both had significant differences among three groups,while TG had no significant difference.Conclusion The expression of PPAR-γ increases in a rabbit model of atherosclerosis;atorvastatin increases the expression of PPAR-γ.