The Influence of High-Frequency Oscillation Ventilation and Conventional Mandatory Ventilation on Lung Injury Development in ARDS Animal

Objective To explore the influence of high-frequency oscillation ventilation (HFOV) and conventional mandatony ventilation (CMV) on lung injury development in ARDS animals and to define the role of HFOV in the treatment of ARDS. Methods ADRS animal models were prepared by lung lavage with saline. After intubation, the animals were treated with HFOV or CMV (n=6). PaCO 2 was maintained between 35～45mmHg by adjusting the parameters of ventilator. The ventilation period was 6h. Lung lavage was given after ventilation, and cytological examination of the lavage fluid was performed. Then the animals were killed and lung tissues were removed for wet/dry weight ratio, light and electron microscopic examination.Results The difference of artery blood gas analyses (pH、PaO 2、PaCO 2) between HFOV and CMV was insignificant. There was no significant difference between HFOV and CMV in the cytological examination of lavage fluid and wet/dry weight measurement. But compared with CMV, HFOV not only reduced the area of lung injury, but also reduced the grade of lung injury in light and electron microscope examination. Conclusion When the same artery blood gas analyses. HFOV can reduce lung injury development significantly. As a lung protection strategy, HFOV can be used in the treatment of ARDS.